Skin aging / wrinkles
LED phototherapy for skin rejuvenation split-face RCT
Lee SY, Park KH, Choi JW, et al. Journal of Photochemistry and Photobiology B. 2007.
A double-blind split-face trial compared 830 nm, 633 nm, combined 633/830 nm, and sham light for facial wrinkles.
Evidence grade
moderate
Effect direction
positive
Panel relevance
panel-replicable
Key findings
- Objective measurements reported wrinkle reductions up to 36% and skin elasticity increases up to 19% compared with baseline.
- Histology showed increased collagen and elastic fibers in treated skin.
- The trial used facial LED exposure twice weekly for 4 weeks with follow-up to 3 months.
Protocol details
| Wavelengths | 633, 830 nm |
|---|---|
| Irradiance | Not reported mW/cm2 |
| Fluence | Not reported J/cm2 |
| Session time | Not reported minutes |
| Frequency | Twice weekly |
| Duration | 4 weeks, with 3-month follow-up |
| Treatment area | One side of the face |
| Device type | Quasimonochromatic LED phototherapy |
Caveats
- Split-face design helps control between-person variation but does not prove long-term maintenance.
- Protocol details do not map perfectly to every consumer panel because irradiance and distance may differ.