Skin aging / wrinkles
Red and amber photobiomodulation for periocular wrinkles RCT
Mota LR, Duarte IDS, Galache TR, et al. Photobiomodulation, Photomedicine, and Laser Surgery. 2023.
A split-face randomized trial compared 660 nm red light and 590 nm amber light at the same dose for periocular wrinkles.
Evidence grade
moderate
Effect direction
positive
Panel relevance
panel-replicable
Key findings
- Red PBM reduced wrinkle volume by 31.6%; amber PBM reduced wrinkle volume by 29.9%.
- Neither treatment improved hydration or viscoelasticity in the reported outcomes.
- The trial used 10 sessions over 4 weeks at 3.8 J/cm2.
Protocol details
| Wavelengths | 590, 660 nm |
|---|---|
| Irradiance | Not reported mW/cm2 |
| Fluence | 3.8 J/cm2 |
| Session time | Not reported minutes |
| Frequency | 10 sessions over 4 weeks |
| Duration | 4 weeks |
| Treatment area | Periocular face area |
| Device type | LED photobiomodulation |
Caveats
- Periocular findings should not be generalized to all body areas or all visible skin aging endpoints.
- Amber light is outside the red/NIR panel wavelengths most products emphasize.